![]() Combining all of that with the capability of tracking creates a theranostic platform that can open the door for very promising new approaches in nanomedicine. These core-shell nanowires have various additional features, including the ability to control them magnetically to guide them to a particular location, to carry drugs, or be to heated with a laser. "The strong magnetization of the nanowires enabled the detection of approximately 10 labeled cells within the brain of a mouse for a period of at least 40 days, which allowed us to trace their exact location and fate in the animal," Martínez-Banderas says. Fluorescent measurements provided an easy and fast method for SiO2 NP. In this work, laboratory-synthesized fluorescent core-shell SiO2 NPs were used to study the fate of these NPs during secondary wastewater treatment. The labeled cells could be tracked either in cell cultures or once injected into a living animal. However, the detection of SiO2 NPs in environmental systems is hindered by the elevated background levels of natural silicon. "The nanowires interacted with cells without compromising their survival, functionality or capacity to proliferate," Martínez-Banderas explains. The nanowire's biocompatibility permitted long-term tracking of the live cells. The nanowires performed well as MRI contrast agents, even at very low concentrations, and the magnetic response could be tuned by altering the thickness of the nanowire shell, the team showed.
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